Pesquisa | Biblioteca Virtual em Saúde

1.

A modular master regulator landscape controls cancer transcriptional identity.

Paull, Evan O; Aytes, Alvaro; Jones, Sunny J; Subramaniam, Prem S; Giorgi, Federico M; Douglass, Eugene F; Tagore, Somnath; Chu, Brennan; Vasciaveo, Alessandro; Zheng, Siyuan; Verhaak, Roel; Abate-Shen, Cory; Alvarez, Mariano J; Califano, Andrea.

Cell ; 184(2): 334-351.e20, 2021 01 21.

Artigo em Inglês | MEDLINE | ID: mdl-33434495

2.

Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer.

Goc, Jeremy; Lv, Mengze; Bessman, Nicholas J; Flamar, Anne-Laure; Sahota, Sheena; Suzuki, Hiroaki; Teng, Fei; Putzel, Gregory G; Eberl, Gerard; Withers, David R; Arthur, Janelle C; Shah, Manish A; Sonnenberg, Gregory F.

Cell ; 184(19): 5015-5030.e16, 2021 09 16.

Artigo em Inglês | MEDLINE | ID: mdl-34407392

3.

Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer.

Zhang, Lei; Li, Ziyi; Skrzypczynska, Katarzyna M; Fang, Qiao; Zhang, Wei; O'Brien, Sarah A; He, Yao; Wang, Lynn; Zhang, Qiming; Kim, Aeryon; Gao, Ranran; Orf, Jessica; Wang, Tao; Sawant, Deepali; Kang, Jiajinlong; Bhatt, Dev; Lu, Daniel; Li, Chi-Ming; Rapaport, Aaron S; Perez, Kristy; Ye, Yingjiang; Wang, Shan; Hu, Xueda; Ren, Xianwen; Ouyang, Wenjun; Shen, Zhanlong; Egen, Jackson G; Zhang, Zemin; Yu, Xin.

Cell ; 181(2): 442-459.e29, 2020 04 16.

Artigo em Inglês | MEDLINE | ID: mdl-32302573

4.

Atlas Drugged.

Chen, Jung-Kuei; Yaffe, Michael B.

Cell ; 177(4): 803-805, 2019 05 02.

Artigo em Inglês | MEDLINE | ID: mdl-31051104

5.

Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities.

Vasaikar, Suhas; Huang, Chen; Wang, Xiaojing; Petyuk, Vladislav A; Savage, Sara R; Wen, Bo; Dou, Yongchao; Zhang, Yun; Shi, Zhiao; Arshad, Osama A; Gritsenko, Marina A; Zimmerman, Lisa J; McDermott, Jason E; Clauss, Therese R; Moore, Ronald J; Zhao, Rui; Monroe, Matthew E; Wang, Yi-Ting; Chambers, Matthew C; Slebos, Robbert J C; Lau, Ken S; Mo, Qianxing; Ding, Li; Ellis, Matthew; Thiagarajan, Mathangi; Kinsinger, Christopher R; Rodriguez, Henry; Smith, Richard D; Rodland, Karin D; Liebler, Daniel C; Liu, Tao; Zhang, Bing.

Cell ; 177(4): 1035-1049.e19, 2019 05 02.

Artigo em Inglês | MEDLINE | ID: mdl-31031003

6.

NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.

Gu, Meidi; Zhou, Xiaofei; Sohn, Jee Hyung; Zhu, Lele; Jie, Zuliang; Yang, Jin-Young; Zheng, Xiaofeng; Xie, Xiaoping; Yang, Jie; Shi, Yaoyao; Brightbill, Hans D; Kim, Jae Bum; Wang, Jing; Cheng, Xuhong; Sun, Shao-Cong.

Nat Immunol ; 22(2): 193-204, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-33398181

7.

Distinct metabolic programs established in the thymus control effector functions of Î³Î´ T cell subsets in tumor microenvironments.

Lopes, Noella; McIntyre, Claire; Martin, Stefania; Raverdeau, Mathilde; Sumaria, Nital; Kohlgruber, Ayano C; Fiala, Gina J; Agudelo, Leandro Z; Dyck, Lydia; Kane, Harry; Douglas, Aaron; Cunningham, Stephen; Prendeville, Hannah; Loftus, Roisin; Carmody, Colleen; Pierre, Philippe; Kellis, Manolis; Brenner, Michael; Argüello, Rafael J; Silva-Santos, Bruno; Pennington, Daniel J; Lynch, Lydia.

Nat Immunol ; 22(2): 179-192, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-33462452

8.

TCF-1 controls T_reg cell functions that regulate inflammation, CD8⁺ T cell cytotoxicity and severity of colon cancer.

Osman, Abu; Yan, Bingyu; Li, Ying; Pavelko, Kevin D; Quandt, Jasmine; Saadalla, Abdulrahman; Singh, Mahendra Pal; Kazemian, Majid; Gounari, Fotini; Khazaie, Khashayarsha.

Nat Immunol ; 22(9): 1152-1162, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-34385712

9.

PTPN2 regulates the generation of exhausted CD8⁺ T cell subpopulations and restrains tumor immunity.

LaFleur, Martin W; Nguyen, Thao H; Coxe, Matthew A; Miller, Brian C; Yates, Kathleen B; Gillis, Jacob E; Sen, Debattama R; Gaudiano, Emily F; Al Abosy, Rose; Freeman, Gordon J; Haining, W Nicholas; Sharpe, Arlene H.

Nat Immunol ; 20(10): 1335-1347, 2019 10.

Artigo em Inglês | MEDLINE | ID: mdl-31527834

10.

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility.

Vecchione, Loredana; Gambino, Valentina; Raaijmakers, Jonne; Schlicker, Andreas; Fumagalli, Arianna; Russo, Mariangela; Villanueva, Alberto; Beerling, Evelyne; Bartolini, Alice; Mollevi, David G; El-Murr, Nizar; Chiron, Marielle; Calvet, Loreley; Nicolazzi, Céline; Combeau, Cécile; Henry, Christophe; Simon, Iris M; Tian, Sun; in 't Veld, Sjors; D'ario, Giovanni; Mainardi, Sara; Beijersbergen, Roderick L; Lieftink, Cor; Linn, Sabine; Rumpf-Kienzl, Cornelia; Delorenzi, Mauro; Wessels, Lodewyk; Salazar, Ramon; Di Nicolantonio, Federica; Bardelli, Alberto; van Rheenen, Jacco; Medema, René H; Tejpar, Sabine; Bernards, René.

Cell ; 165(2): 317-30, 2016 Apr 07.

Artigo em Inglês | MEDLINE | ID: mdl-27058664

11.

Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules.

Grabocka, Elda; Bar-Sagi, Dafna.

Cell ; 167(7): 1803-1813.e12, 2016 Dec 15.

Artigo em Inglês | MEDLINE | ID: mdl-27984728

12.

Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages.

Bohn, Toszka; Rapp, Steffen; Luther, Natascha; Klein, Matthias; Bruehl, Till-Julius; Kojima, Nobuhiko; Aranda Lopez, Pamela; Hahlbrock, Jennifer; Muth, Sabine; Endo, Shogo; Pektor, Stefanie; Brand, Almut; Renner, Kathrin; Popp, Vanessa; Gerlach, Katharina; Vogel, Dennis; Lueckel, Christina; Arnold-Schild, Danielle; Pouyssegur, Jacques; Kreutz, Marina; Huber, Magdalena; Koenig, Jochem; Weigmann, Benno; Probst, Hans-Christian; von Stebut, Esther; Becker, Christian; Schild, Hansjoerg; Schmitt, Edgar; Bopp, Tobias.

Nat Immunol ; 19(12): 1319-1329, 2018 12.

Artigo em Inglês | MEDLINE | ID: mdl-30397348

13.

Blockade of the checkpoint receptor TIGIT prevents NK cell exhaustion and elicits potent anti-tumor immunity.

Zhang, Qing; Bi, Jiacheng; Zheng, Xiaodong; Chen, Yongyan; Wang, Hua; Wu, Wenyong; Wang, Zhengguang; Wu, Qiang; Peng, Hui; Wei, Haiming; Sun, Rui; Tian, Zhigang.

Nat Immunol ; 19(7): 723-732, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29915296

14.

Targeting of Fn14 Prevents Cancer-Induced Cachexia and Prolongs Survival.

Johnston, Amelia J; Murphy, Kate T; Jenkinson, Laura; Laine, David; Emmrich, Kerstin; Faou, Pierre; Weston, Ross; Jayatilleke, Krishnath M; Schloegel, Jessie; Talbo, Gert; Casey, Joanne L; Levina, Vita; Wong, W Wei-Lynn; Dillon, Helen; Sahay, Tushar; Hoogenraad, Joan; Anderton, Holly; Hall, Cathrine; Schneider, Pascal; Tanzer, Maria; Foley, Michael; Scott, Andrew M; Gregorevic, Paul; Liu, Spring Yingchun; Burkly, Linda C; Lynch, Gordon S; Silke, John; Hoogenraad, Nicholas J.

Cell ; 162(6): 1365-78, 2015 Sep 10.

Artigo em Inglês | MEDLINE | ID: mdl-26359988

15.

Clinical management of metastatic colorectal cancer in the era of precision medicine.

Ciardiello, Fortunato; Ciardiello, Davide; Martini, Giulia; Napolitano, Stefania; Tabernero, Josep; Cervantes, Andres.

CA Cancer J Clin ; 72(4): 372-401, 2022 07.

Artigo em Inglês | MEDLINE | ID: mdl-35472088

16.

An essential mesenchymal function for miR-143/145 in intestinal epithelial regeneration.

Chivukula, Raghu R; Shi, Guanglu; Acharya, Asha; Mills, Eric W; Zeitels, Lauren R; Anandam, Joselin L; Abdelnaby, Abier A; Balch, Glen C; Mansour, John C; Yopp, Adam C; Maitra, Anirban; Mendell, Joshua T.

Cell ; 157(5): 1104-16, 2014 May 22.

Artigo em Inglês | MEDLINE | ID: mdl-24855947

17.

KRAS and YAP1 converge to regulate EMT and tumor survival.

Shao, Diane D; Xue, Wen; Krall, Elsa B; Bhutkar, Arjun; Piccioni, Federica; Wang, Xiaoxing; Schinzel, Anna C; Sood, Sabina; Rosenbluh, Joseph; Kim, Jong W; Zwang, Yaara; Roberts, Thomas M; Root, David E; Jacks, Tyler; Hahn, William C.

Cell ; 158(1): 171-84, 2014 Jul 03.

Artigo em Inglês | MEDLINE | ID: mdl-24954536

18.

YAP1 takes over when oncogenic K-Ras slumbers.

Greten, Florian R.

Cell ; 158(1): 11-2, 2014 Jul 03.

Artigo em Inglês | MEDLINE | ID: mdl-24995973

19.

Î³Î´ T cells are effectors of immunotherapy in cancers with HLA class I defects.

de Vries, Natasja L; van de Haar, Joris; Veninga, Vivien; Chalabi, Myriam; Ijsselsteijn, Marieke E; van der Ploeg, Manon; van den Bulk, Jitske; Ruano, Dina; van den Berg, Jose G; Haanen, John B; Zeverijn, Laurien J; Geurts, Birgit S; de Wit, Gijs F; Battaglia, Thomas W; Gelderblom, Hans; Verheul, Henk M W; Schumacher, Ton N; Wessels, Lodewyk F A; Koning, Frits; de Miranda, Noel F C C; Voest, Emile E.

Nature ; 613(7945): 743-750, 2023 01.

Artigo em Inglês | MEDLINE | ID: mdl-36631610

20.

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis.

Wei, Jun; Long, Lingyun; Yang, Kai; Guy, Cliff; Shrestha, Sharad; Chen, Zuojia; Wu, Chuan; Vogel, Peter; Neale, Geoffrey; Green, Douglas R; Chi, Hongbo.

Nat Immunol ; 17(3): 277-85, 2016 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-26808230

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